Bayesian statistical methods are revolutionizing the design and analysis of clinical trials across all phases by allowing continuous adaptation and the incorporation of prior knowledge. Unlike the frequentist approach, which typically relies on fixed sample sizes and...
Dimethyl fumarate (DMF) is a medication used primarily to treat relapsing forms of multiple sclerosis (MS). Monomethyl fumarate (MMF) is a derivative of fumaric acid that contains a single methyl group attached to the fumarate backbone. They belong to a class of drugs...
Phase 1 clinical trials, including first-in-human studies, bridge preclinical and clinical drug development by being the first stage in drug development programs during which a New Chemical Entity (NCE) or Investigational Medicinal Product (IMP) is evaluated in...
The efficient and timely enrollment of study participants is key to the success of clinical trials. However, the process of clinical trial recruitment has consistently been associated with challenges. For example, up to 85% of clinical trials face difficulties to...
Understanding the Vasoconstriction Assay for Topical Corticosteroids In general, traditional pharmacokinetic (PK) endpoint studies, comparing the rate and extent of absorption of the drug estimated from the drug concentrations in a biological fluid, are a strong...
Isomers are molecules that share the same molecular formula but have different structures. This means they contain the same number of atoms of each element, but these atoms are arranged differently. There are two main forms of isomerism: structural (or constitutional)...
