Impact of Calibrator Concentrations and Their Distribution on Accuracy of Quadratic Regression for LC-MS Bioanalysis
PRESENTED TO: BioPharma Services Inc.
PRESENTED BY: A. TAN, K. AWAIYE, F. TRABELSI
PURPOSE
Impact of Calibrator Concentrations and Their Distribution on Accuracy of Quadratic Regression for LC-MS Bioanalysis – Despite the common use of quadratic regression in LC-MS bioanalysis, how calibrator concentrations should be determined is still vague. Both the number and concentrations of calibrators are usually selected arbitrarily to each bioanalytical scientist’s preference, without necessary regards to their possible impact on the accuracy of quadratic regression. The purpose of this research is to evaluate the impact of calibrator concentrations on accuracy of quadratic regression and to find new approaches with improved accuracy and robustness for LC-MS bioanalysis.
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