Bioanalytical Assay List

BioPharma Services has completed a wide range of Bioanalytical Assays in various biological matrices.

The methods tabulated below vary from Qualified to Fully Validated Methods.

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List of Validated LC-MS/MS Bioanalytical Methods

COMPOUNDS	MATRIX	LLOQ	ANTICOAGULANT
1-Aminoindan	Human Plasma	20 pg/mL	K2EDTA
Abiraterone	Human Plasma	0.2 ng/mL	K2EDTA
Acalabrutinib/Metabolite M27	Human Plasma	1/1 ng/mL	K2EDTA
Acetaminophen	Human Plasma	75 ng/mL	K2EDTA
Acetaminophen (with Tramadol)	Human Plasma	75 ng/mL	K2EDTA
Acetylsalicylic Acid	Human Plasma	2.5 ng/mL	Sodium Fluoride/Potassium Oxalate
Albendazole/Albendazole Sulfoxide (LR)	Human Plasma	0.1/1 ng/mL	K2EDTA
Ambrisentan	Human Plasma	50 ng/mL	K2EDTA
Amifampridine	Human Plasma	150 pg/mL	K2EDTA
Amlodipine	Human Plasma	5 pg/mL	K2EDTA
Amlodipine (with Lisinopril)	Human Plasma	0.15 ng/mL	K2EDTA
Amphetamine (D/L) Chiral	Human Plasma	0.2/0.2 ng/mL	K2EDTA
Amphetamine (D/L) Chiral	Human Plasma	50 /50 pg/mL	K2EDTA
Apalutamide	Human Plasma	5 ng/mL	K2EDTA
Apixaban	Human Plasma	1 ng/mL	K2EDTA
Apomorphine	Human Plasma	50 pg/mL	K2EDTA
Aprepitant	Human Plasma	25 ng/mL	K2EDTA
Aripiprazole	Human Plasma	0.2 ng/mL	K2EDTA
Atovaquone (with Proguanil)	Human Plasma	25 ng/mL	K2EDTA
Axitinib	Human Plasma	0.5 ng/mL	K2EDTA
Azithromycin	Human Plasma	1 ng/mL	K2EDTA
Bexarotene	Human Plasma	1 ng/mL	K2EDTA
Bisoprolol	Human Plasma	0.2 ng/mL	K2EDTA
Bromazepam	Hunam Plasma	1 ng/mL	K2EDTA
Budesonide	Human Plasma	3 pg/mL	Sodium Fluoride/Potassium Oxalate
Buprenorphine	Human Plasma	1 pg/mL	K2EDTA
Buprenorphine/Norbuprenorphine (with Naloxone)	Human Plasma	25/20 pg/mL	K3EDTA
Carglumic Acid (high range)	Human Plasma	25 ng/mL	Sodium Heparin
Carglumic Acid (low range)	Human Plasma	10 ng/mL	Sodium Heparin
CBD (with THC & 11-OH-THC)	Human Plasma	50 pg/mL	K2EDTA
Cefixime	Human Plasma	50 ng/mL	K2EDTA
Celecoxib	Dog Plasma	1 ng/mL	K3EDTA
Celecoxib	Dog Synovial Fluid	1 ng/mL	K3EDTA
Celecoxib	Rat Plasma	1 ng/mL	K3EDTA
Celecoxib	Human Plasma	1 ng/mL	K2EDTA
Chlorphenamine Maleate (Chiral)	Human Plasma	50/50 pg/mL	K2EDTA
Chlorzoxazone	Human Plasma	0.1 µg/mL	K2EDTA
Ciprofloxacin	Human Plasma	10 ng/mL	K2EDTA
Citalopram	Human Plasma	0.5 ng/mL	K2EDTA
Clindamycin	Human Plasma	25 ng/mL	K2EDTA
Clobazam/N-Desmethyclobazam	Human Plasma	1/0.35 ng/mL	K2EDTA
Clobazam/N-Desmethyclobazam	Human Plasma	1/3 ng/mL	K2EDTA
Clobetasol Propionate	Human Plasma	40 pg/mL	K2EDTA
Clonidine	Human Plasma	10 pg/mL	K2EDTA
Cysteamine	Human Plasma	20 ng/mL	Sodium Heparin
Dabigatran (free)	Human Plasma	1 ng/mL	K2EDTA
Dabigatran (total)	Human Plasma	1 ng/mL	K2EDTA
Dapsone	Human Plasma	5 ng/mL	Sodium Fluoride/Potassium Oxalate
Dasatinib	Human Plasma	1 ng/mL	K2EDTA
Deferasirox	Human Plasma	40 ng/mL	K2EDTA
Deferiprone	Human Serum	50 ng/mL	N/A
Desoximetasone	Human Plasma	25 pg/mL	K2EDTA
Dexlansoprazole	Human Plasma	1 ng/mL	K2EDTA
Dexmethylphenidate	Human Plasma	100 pg/mL	Sodium Fluoride/Potassium Oxalate
Diazepam	Human Plasma	5 ng/mL	K2EDTA
Dichlorphenamide	Human Plasma	1 ng/mL	K2EDTA
Dienogest	Human Plasma	1 ng/mL	K2EDTA
Dipyridamole	Human Plasma	7 ng/mL	K2EDTA
Dofetilide (with Mexiletine)	Human Plasma	20 pg/mL/ 3 ng/mL	K2EDTA
Dolutegravir (with Lamotrigine and Tenofovir)	Human Plasma	20 ng/mL	K2EDTA
Donepezil	Human Plasma	100 pg/mL	K2EDTA
Doxepine/Nordoxepin (High Range)	Human Plasma	100/100 pg/mL	K2EDTA
Doxepine/Nordoxepin (Low Range)	Human Plasma	25/25 pg/mL	K2EDTA
Doxycycline	Human Plasma	20 ng/mL	K2EDTA
Doxylamine (qualified method)	Human Plasma	0.25 ng/mL	K2EDTA
Droxidopa	Human Plasma	10 ng/mL	K2EDTA
Dutasteride	Human Plasma	30 pg/mL	K2EDTA
Edaravone (free)	Human Plasma	2 ng/mL	K2EDTA
Edaravone Sulfate/Edaravone Glucuronide	Human Plasma	5/2 ng/mL	K2EDTA
Efavirenz	Human Plasma	10 ng/mL	K2EDTA
Elagolix	Human Plasma	5 ng/mL	K2EDTA
Emtricitabine	Human Plasma	10 ng/mL	K2EDTA
Enzalutamide	Human Plasma	510 ng/mL	K2EDTA
Eplerenone (with Furosemide)	Human Plasma	15 ng/mL	K2EDTA
Erlotinib	Human Plasma	5 ng/mL	K2EDTA
Esomeprazole	Human Plasma	1.5 ng/mL	K2EDTA
Ethacrynic Acid	Human Plasma	0.5 pg/mL	K2EDTA
Ethinyl Estradiol (with Norethindrone)	Human Plasma	1 pg/mL	K2EDTA
Everolimus	Whole Blood	0.2 ng/mL	K2EDTA
Ezogabine	Human Plasma	5 ng/mL	K2EDTA
Felbamate	Dog Plasma	200 ng/mL	K2EDTA
Felbamate	Human Plasma	200 ng/mL	K2EDTA
Finasteride	Human Plasma	0.5 pg/mL	K2EDTA
Fingolimod	Whole Blood	5 pg/mL	K2EDTA
Fingolimod Phosphate	Whole Blood	25 pg/mL	K2EDTA
Flecainide	Human Plasma	0.8 ng/mL	K2EDTA
Fluconazole	Human Plasma	50 ng/mL	K2EDTA
Fluticasone Furoate	Human Plasma	0.5 pg/mL	K3EDTA
Fluticasone Propionate (with Salmeterol)	Human Plasma	1 pg/mL	K2EDTA
Formoterol	Human Plasma	0.3 pg/mL	Sodium Fluoride/Potassium Oxalate
Furosemide (with Eplerenone)	Human Plasma	15 ng/mL	K2EDTA
Gabapentin	Human Plasma	10 ng/mL	K2EDTA
Gamma Hydroxybutyrate (GHB)	Human Plasma	0.5 µg/mL	K2EDTA
Gefitinib	Human Plasma	1 ng/mL	K2EDTA
Gepirone	Human Plasma	20/20/20 pg/mL	K2EDTA
Gliclazide	Human Plasma	5 ng/mL	K2EDTA
Hydrocodone	Human Plasma	0.1 ng/mL	K2EDTA
Hydroxymethyl Tolterodine (5HMT)	Human Plasma	20 pg/mL	K2EDTA
Ibrutinib (High Range)	Human Plasma	1.50 ng/mL	K2EDTA
Ibrutinib (Low Range)	Human Plasma	0.5 ng/mL	K2EDTA
Ibuprofen	Human Plasma	100 ng/mL	K2EDTA
Idelalisib	Human Plasma	10 ng/mL	K2EDTA
Imatinib/N-Desmethyl Imatinib	Human Plasma	10/2 ng/mL	K2EDTA
Indapamide	Human Whole Blood	0.25 ng/mL	K2EDTA
Ketamine/Norketamine	Human Plasma	0.4/4 ng/mL	K2EDTA
Lacosamide	Human Plasma	100 ng/mL	K2EDTA
Lamivudine (with Dolutegravir & Tenofovir)	Human Plasma	50 ng/mL	K2EDTA
Lamotrigine	Human Plasma	10 ng/mL	K2EDTA
Lansoprazole	Human Plasma	1 ng/mL	K2EDTA
Lenalidomide	Human Plasma	1 ng/mL	K2EDTA
Lenvatinib	Human Plasma	0.5 ng/mL	K2EDTA
Leuprolide	Human Plasma	50 pg/mL	K2EDTA
Levetiracetam	Human Plasma	0.2 µg/mL	K2EDTA
Levetiracetam	Human Plasma	50 ng/mL	K2EDTA
Levomilnacipran	Human Plasma	1 ng/mL	K2EDTA
Levothyroxine	Human Serum	10 ng/mL	N/A
Lidocaine (with Prilocaine)	Human Plasma	100 pg/mL	K2EDTA
Lisdexamfetamine/D-Amphetamine	Human Plasma	0.4/0.8 ng/mL	K2EDTA
Lisinopril (with Amlodipine)	Human Plasma	1.5 ng/mL	K2EDTA
Loxapine/7 and 8-Hydroxy Loxapine	Human Plasma	10/10/10 pg/mL	K2EDTA
Macitentan	Human Plasma	1 ng/mL	K2EDTA
Mesalamine	Human Plasma	2 ng/mL	K2EDTA
Metformin	Human Plasma	6 ng/mL	K2EDTA
Methylnaltrexone	Human Plasma	0.1 ng/mL	K2EDTA
Methylphenidate	Human Plasma	20 pg/mL	Sodium Fluoride/Potassium Oxalate
Methylphenidate	Human Plasma	100 pg/mL	Sodium Fluoride/Potassium Oxalate
Metolazone	Human Plasma	0.5 ng/mL	K2EDTA
Metoprolol	Human Plasma	0.6 ng/mL	K2EDTA
Mexiletine (with Dofetilide)	Human Plasma	3 ng/mL	K2EDTA
Midostaurin/CGP62221/CGP52421	Human Plasma	7.5/5/5 ng/mL	K2EDTA
Mirtazapine	Human Plasma	0.25 ng/mL	K2EDTA
Mometasone Furorate	Human Plasma	0.5 pg/mL	K3EDTA
Monomethyl Fumarate	Human Plasma	25 ng/mL	Sodium Fluoride/Potassium Oxalate
Morphine/Morphine 6-Glucuronide	Human Plasma	0.2/0.4 ng/mL	K2EDTA
Naloxone (Free)	Human Urine	0.4 ng/mL	N/A
Naloxone (Free) (with Buprenorphine and Norbuprenorphine)	Human Plasma	3 pg/mL	K2EDTA
Naloxone (with Oxycodone)	Human Plasma	1 pg/mL	K2EDTA
Naloxone-3 β D glucoronide	Human Plasma	50 pg/mL	K3EDTA
Naltrexone/6β-Naltrexol (High Range)	Human Plasma	20/20 pg/mL	K2EDTA
Naltrexone/6β-Naltrexol (Low Range)	Human Plasma	0.5/0.5 pg/mL	K2EDTA
Nebivolol	Human Plasma	100 pg/mL	K2EDTA
Neratinib	Human Plasma	50 pg/mL	K2EDTA
Nicotine/Cotinine	Human Plasma	0.2/2 ng/mL	K2EDTA
Nifedipine	Human Plasma	0.1 ng/mL	K2EDTA
Nitrofurantoin	Human Plasma	0.2 ng/mL	K2EDTA
Nitroglycerin (NTG), 1,2-DNG/1,3-DNG	Human Plasma	20/20/20 pg/mL	K2EDTA
Norethindrone (with ethinyl estradiol)	Human Plasma	25 pg/mL	K2EDTA
Nortriptyline	Human Plasma	0.2 ng/mL	K2EDTA
Obeticholic Acid	Human Plasma	500/500/100 pg/mL	K2EDTA
Octreotide	Rabbit Plasma	0.25 ng/mL	K2EDTA
Omeprazole	Human Plasma	1 ng/mL	K2EDTA
Oxycodone	Human Plasma	0.25 ng/mL	K2EDTA
Oxycodone (with naloxone)	Human Plasma	50 pg/mL	K2EDTA
Oxymorphone/6-Hydroxyoxymorphone	Human Plasma	5/10/100 pg/mL	K2EDTA
Oxymorphone/Naloxone/Oxycodone	Human Plasma	50/25 pg/mL	K2EDTA
Palbociclib	Human Plasma	0.5 ng/mL	K2EDTA
Paliperidone	Human Plasma	100 pg/mL	K2EDTA
Pazopanib	Human Plasma	100 ng/mL	K2EDTA
Perindopril/ Perindoprilat/Indapamide	Human Plasma	500/250/100 pg/mL	K2EDTA
Pirfenidone	Human Plasma	100 ng/mL	K2EDTA
Pramipexole (with Rasagaline)	Human Plasma	20 pg/mL	K2EDTA
Pramipexole (with Rasagaline)	Human Plasma	10 pg/mL	K2EDTA
Pregabalin	Human Plasma	25 ng/mL	K2EDTA
Prilocaine (with Lidocaine)	Human Plasma	25 pg/mL	K2EDTA
Primidone	Human Plasma	20 ng/mL	K2EDTA
Progesterone	Human Plasma	50 pg/mL	K2EDTA
Progesterone	Human Plasma	0.2 ng/mL	K2EDTA
Proguanil (with Atovaquone)	Human Plasma	1 ng/mL	K2EDTA
Psilocybin/Psilocin	Human Plasma	500/100 pg/mL	K2EDTA
Pyridoxine (qualified method)	Human Plasma	50 pg/mL	K2EDTA
Rasagline (with Pramipexole)	Human Plasma	20 pg/mL	K2EDTA
Rasagline (with Pramipexole)	Human Plasma	10 pg/mL	K2EDTA
Regorafenib/Regorafenib-N-Oxide (M2)	Human Plasma	10/4 ng/mL	K3EDTA
Ribociclib	Human Plasma	2 ng/mL	K2EDTA
Risperidone	Human Plasma	0.1 ng/mL	K2EDTA
Rivaroxaban	Dog Plasma	0.5 ng/mL	K2EDTA
Rivaroxaban	Human Plasma	0.5 ng/mL	K2EDTA
Rizatriptan	Human Plasma	0.15 ng/mL	K2EDTA
Roflumilast	Human Plasma	20 pg/mL	K2EDTA
Rosuvastatin	Human Plasma	100 pg/mL	K2EDTA
Sacubitril (High Range) (with Valsartan)	Human Plasma	5 ng/mL	K2EDTA
Sacubitril (Low Range) (with Valsartan)	Human Plasma	1 ng/mL	K2EDTA
Sacubitril (Mid Range) (with Valsartan)	Human Plasma	1 ng/mL	K2EDTA
Salicyclic Acid	Human Plasma	25 ng/mL	Sodium Fluoride/Potassium Oxalate
Salmeterol (with Fluticasone propionate)	Human Plasma	1 pg/mL	K2EDTA
Sildenafil	Human Plasma	0.75 ng/mL	K2EDTA
Silodosin/Silodosin-β-D-Glucuronide	Human Plasma	0.5/0.5 ng/mL	K2EDTA
Sitagliptin	Human Plasma	10 ng/mL	K2EDTA
Sitagliptin	Human Plasma	1 ng/mL	K2EDTA
Sofosbuvir	Human Plasma	5 ng/mL	K2EDTA
Solifenacin (with Tamsulosin)	Human Plasma	100 pg/mL	K2EDTA
Sulfamethoxazole (with Trimethoprim)	Human Plasma	250/10 ng/mL	K2EDTA
Tacrolimus	Whole Blood	100 pg/mL	K2EDTA
Tacrolimus (LR)	Whole Blood	50 pg/mL	K2EDTA
Tadalafil	Human Plasma	3 ng/mL	K2EDTA
Tamsulosin (with Solifenacin)	Human Plasma	100 pg/mL	K2EDTA
Tapentadol	Human Plasma	0.5 ng/mL	K2EDTA
Telmisartan	Human Plasma	2 ng/mL	K3EDTA
Tenofovir (with Dolutegravir and Lamivudine)	Human Plasma	5 ng/mL	K2EDTA
Tenofovir Alafenamide	Human Plasma	1 ng/mL	K2EDTA
Tetrabenazine/α-and β-hydroxy Tetrabenazine	Human Plasma	20 pg/mL/0.25/0.25 ng/mL	K2EDTA
Thalidomide	Human Plasma	10 ng/mL	K2EDTA
THC/11-OH THC (with CBD)	Human Plasma	100/100/100 pg/mL	K2EDTA
Theophylline	Human Plasma	50 ng/mL	K2EDTA
Thiorphan	Human Plasma	2 ng/mL	K2EDTA
Ticagrelor/Deshydroxyethoxy Ticagrelor	Human Plasma	5/2.5 ng/mL	K2EDTA
Tiotropium	Human Plasma	0.5 pg/mL	K2EDTA
Triamcinolone Acetonide	Human Plasma	10 pg/mL	K2EDTA
Trientine/N1-Acetyitriethyienetetramine	Human Plasma	10 ng/mL	K2EDTA
Trimethoprim (with sulfamethoxazole)	Human Plasma	10 ng/mL	K2EDTA
Ulipristal Acetate	Human Plasma	0.25 ng/mL	K2EDTA
Ulipristal Acetate/N-Desmethyl Ulipristal Acetate	Human Plasma	1/0.5 ng/mL	K2EDTA
Valsartan (with hydrochlorothiazide)	Human Plasma	20 ng/mL	K2EDTA
Valsartan (with Sacubitril) High Range	Human Plasma	10 ng/mL	K2EDTA
Valsartan (with Sacubitril) Low Range	Human Plasma	1 ng/mL	K2EDTA
Valsartan (with Sacubitril) Med Range	Human Plasma	2.5 ng/mL	K2EDTA
Varenicline	Human Plasma	100 pg/mL	K2EDTA
Vigabatrin	Human Plasma	0.25 µg/mL	K2EDTA
Vildagliptin	Human Plasma	2 ng/mL	K2EDTA
Voriconazole	Human Plasma	10 ng/mL	K2EDTA

List of Methods in Development and/or Validation

COMPOUNDS	MATRIX	LLOQ	ANTICOAGULANT
Apremilast	Human Plasma	1 ng/mL	K2EDTA
Diltiazem	Human Plasma	3 ng/mL	K2EDTA
Doxepin/Nordoxepin (Low Range)	Human Plasma	5/5 pg/mL	K2EDTA
Exemestane	Human Plasma	0.05 ng/mL	K2EDTA
Hydrochlorothiazide (with Valsartan)	Human Plasma	1 ng/mL	K2EDTA
Hydromorphone	Human Plasma	50 pg/mL	K2EDTA
Levodopa/Carbidopa	Human Plasma	10/1 ng/mL	K2EDTA
Linagliptin	Human Plasma	0.05 ng/mL	K2EDTA
6-Mercaptopurine	Human Plasma	300 pg/mL	K2EDTA
Venlafaxine/O-Desmethyl Venlafaxine *	Human Plasma	0.5/1 ng/mL	K2EDTA
*Method developed and waiting to be validated

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