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The investigation of variability of the pharmacokinetics of mesalamine from mesalamine formulations

PRESENTED TO: BioPharma Services Inc.
PRESENTED BY: Juan He*, Masood Bhatti, and Lorelei Lutter

ABSTRACT

Purpose: Mesalamine, which is also called 5-aminosalicylic acid or 5-ASA, is an amino-salicylate anti-inflammatory drug indicated for the treatment of ulcerative colitis. There are several oral delayed release and sustained release mesalamine formulations. The pharmacokinetic profiles of Asacol®, Pentasa®, and Lialda® are included in this investigation.

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THE INVESTIGATION OF VARIABILITY OF THE PHARMACOKINETICS OF MESALAMINE FROM MESALAMINE FORMULATIONS

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